The BBC reported the Financial Services Authority referred the case to the Thames Valley Police Economic Crime Unit who carried out an investigation into corruption, fraud and money laundering.
Lynden Scourfield, 50, is charged with one count of conspiracy to corrupt, three counts of fraudulent trading and one count of money laundering and Mark Dobson, 52, is charged with one count of conspiracy to corrupt.
Both were senior managers based at Reading and Bishopsgate, the Crown Prosecution said.
The alleged offences originated from HBOS's Impaired Assets team based at the Reading branch.
David Mills, 56, and Michael Bancroft, 69, of Quayside Corporate Services, a turnaround consultancy, have also been charged along with a fifth man, John Cartwright, 68.
The other defendants are three of the men's wives, Jacqueline Scourfield, 50, Alison Mills, 47, and Beverley Bancroft, 64.
All eight will appear before Reading Magistrates' Court on 18 January.
