Staff working for the trade body in Exeter have been informed.
Speaking at today's NACFB Expo in Birmingham Adam Tyler, NACFB chief executive, said: "We've run the figures and are confident that the association will still turn a profit after the move."
He explained the move made sense given that he spends three days a week in London already lobbying government and working with other trade bodies.
NACFB finance director Andrew Bullard revealed he expects the trade body to make a profit of £50,000 next year.
Tyler also announced several new initiatives from the NACFB including a revamped website designed partly to drive more SMEs to brokers offering commercial finance.
A new lead generation panel has also been added to the site open to a limited number of members initially.
Tyler said: "Obviously this is a new hub and we would expect it to grow over time. As it does we will be widening the panel."
The hub will filter SME leads regionally and to specialists in asset finance, commercial mortgages and other niches.
Commission will be split with 75% going to brokers arranging the deal, 15% to the introducing broker and 10% staying with the hub.
Tyler added that further training and development tools had been added to the new website.
And he added: "This is more fit for purpose and helps me show others how good our members are."
Tyler also noted that it was likely NatWest would stop being patrons of the NACFB this year but that he hoped RBS would remain with the association.